Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway.

@article{Chen2010SimvastatinPO,
  title={Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway.},
  author={Pei-yu Chen and Jui-Sheng Sun and Y H Tsuang and Ming-Hong Chen and Pei-Wei Weng and Feng-huei Lin},
  journal={Nutrition research},
  year={2010},
  volume={30 3},
  pages={191-9}
}
Statins inhibit 3-hydroxy-3-methylglutaryl-coenzyme A reductase, which catalyzes the conversion of 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, a rate-limiting step in cholesterol synthesis. Statins are able to reduce cardiovascular risk in hypercholesterolemic patients. In recent years, the possible effect of statins on bone tissue has received particular attention. The present study was undertaken to understand the events of osteoblast differentiation induced by statins. Our… CONTINUE READING
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