Simvastatin prevents proliferation and bone metastases of lung adenocarcinoma in vitro and in vivo.

@article{Liu2013SimvastatinPP,
  title={Simvastatin prevents proliferation and bone metastases of lung adenocarcinoma in vitro and in vivo.},
  author={Huaxu Liu and Z Wang and Yang Li and Wentong Li and Y Chen},
  journal={Neoplasma},
  year={2013},
  volume={60 3},
  pages={240-6}
}
OBJECTIVES To explore the mechanism about how HMG-CoA reductase (HMGR) inhibitor inhibit proliferation and bone metastases of lung adenocarcinoma in vitro and in vivo. METHODS The HMGR inhibitor simvastatin, human lung cancer cell line A549 and Balb/c nude mouse were used in this study. The mice were randomly divided into 2 groups: control group (0.9% NaCl solution, i.v.) and simvastatin group (5mg/kg simvastatin, i.v.). A scratch assay using A549 cell monolayer was also tested. An invasion… CONTINUE READING
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P 53 controls cancer cell invasion by inducing the mdm 2mediated degradation of slug

  • SP WANG, WL WANG, YL CHANG, CT WU, YC CHAO
  • Nat Cell Biol
  • 2009

Growth - inhibitory and tumorsuppressive functions of p 53 depend on its repression of cd 44 expression

  • S GODAR, TA INCE, GW BELL, D FELDSER, JL DONAHER
  • Cell
  • 2008

Tgfbeta primes breast tumors for lung metastasis seeding through angiopoietinlike 4

  • D PADUA, XH ZHANG, Q WANG, C NADAL, WL GERALD
  • Cell
  • 2008

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