Simvastatin prevents inflammation-induced aortic stiffening and endothelial dysfunction.

@article{Wallace2010SimvastatinPI,
  title={Simvastatin prevents inflammation-induced aortic stiffening and endothelial dysfunction.},
  author={Sharon M. L. Wallace and Kaisa M. M{\"a}ki-Pet{\"a}j{\"a} and Joseph Cheriyan and Edward H. Davidson and Lynne Cherry and Carmel M McEniery and Naveed Sattar and Ian B. Wilkinson and Rajesh K. Kharbanda},
  journal={British journal of clinical pharmacology},
  year={2010},
  volume={70 6},
  pages={
          799-806
        }
}
AIMS The aim of this study was to determine whether simvastatin would protect against inflammation-induced aortic stiffening and endothelial dysfunction. METHODS Aortic pulse wave velocity (aPWV) and flow-mediated dilatation (FMD) were assessed three times, at baseline, after a 14 day administration of simvastatin or placebo and 8 h after Salmonella typhi vaccination in 50 healthy subjects. RESULTS Following vaccination there was a significant increase in aPWV in the placebo group (5.80 ± 0… CONTINUE READING
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