Simvastatin maintains osteoblastic viability while promoting differentiation by partially regulating the expressions of estrogen receptors α.


BACKGROUND Statin is a specific inhibitor of 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase, a rate-limiting enzyme involved in the cholesterol synthesis pathway. In addition to their long-known efficacy for lowering cholesterol, statins have also been reported to possess anabolic effects on bone. Simvastatin is reported to increase cancellous… (More)
DOI: 10.1016/j.jss.2010.12.029


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics