Simvastatin locally applied from a biodegradable coating of osteosynthetic implants improves fracture healing comparable to BMP-2 application.

@article{Pauly2009SimvastatinLA,
  title={Simvastatin locally applied from a biodegradable coating of osteosynthetic implants improves fracture healing comparable to BMP-2 application.},
  author={Stephan Pauly and Franziska Luttosch and Marcin Morawski and N. P. Haas and G. Schmidmaier and Britt Wildemann},
  journal={Bone},
  year={2009},
  volume={45 3},
  pages={
          505-11
        }
}
Many clinical and experimental investigations address the influence of statins on bone formation and fracture healing. Simvastatin was shown to increase the expression of Bone morphogenetic protein (BMP-2), which is one of the most potent growth factors targeting bone formation. In this study, the effect of simvastatin locally applied from a bioactive polymer coating of implants on fracture healing was investigated. A closed fracture of the right tibia of 5-month-old Sprague-Dawley rats was… CONTINUE READING

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