Simvastatin inhibits noradrenaline-induced hypertrophy of cultured neonatal rat cardiomyocytes.

@article{Luo2001SimvastatinIN,
  title={Simvastatin inhibits noradrenaline-induced hypertrophy of cultured neonatal rat cardiomyocytes.},
  author={J. S. Luo and Fukang Xie and W. W. Zhang and Xiang Ma and J X Guan and Xiangping Chen},
  journal={British journal of pharmacology},
  year={2001},
  volume={132 1},
  pages={159-64}
}
1. Oxidative mechanisms have been implicated in neonatal cardiomyocyte hypertrophy. We and others have shown that a HMG-CoA reductase inhibitor preserves endogenous antioxidant enzyme activity and inhibits cardiac hypertrophy in vivo. We therefore have examined whether noradrenaline (NA) induces the generation of reactive oxygen species (ROS) during its induction of neonatal cardiomyocyte hypertrophy and whether simvastatin, a HMG-CoA reductase inhibitor, attenuates ROS production and thus NA… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Protective e€ect of ̄uvastatin sodium(XU-62-320), a 3-hydroxy3-methylglutaryl coenzyme A(HMG-CoA) reductase inhibitor, on oxidative modi®cation of human low-density lipoprotein

  • K. SUZUMURA, M. YZSUHARA, K. TANAKA, T. SUZUKI
  • adrenergic response. J. Clin. Invest.,
  • 1999
1 Excerpt

Similar Papers

Loading similar papers…