Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration.

@article{Porter2002SimvastatinIH,
  title={Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration.},
  author={Karen E Porter and Jagjeeth B Naik and Neil A. Turner and Timothy Dickinson and Matthew M. Thompson and Nicholas J. M. London},
  journal={Journal of vascular surgery},
  year={2002},
  volume={36 1},
  pages={150-7}
}
OBJECTIVE Migration and proliferation of vascular smooth muscle cells (SMCs) contributes to intimal hyperplasia in saphenous vein (SV) bypass grafts, which leads to patency-threatening stenosis. Evidence for the involvement of basement membrane-degrading matrix metalloproteinases (MMPs) and growth factors in mediating SMC migration and proliferation has been presented in a number of in vitro and in vivo models. 3-Hydroxy-3 methylglutaryl CoA reductase inhibitors (statins) are widely used in… CONTINUE READING

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