Simvastatin induces neuroprotection in 6-OHDA-lesioned PC12 via the PI3K/AKT/caspase 3 pathway and anti-inflammatory responses.

@article{Xu2013SimvastatinIN,
  title={Simvastatin induces neuroprotection in 6-OHDA-lesioned PC12 via the PI3K/AKT/caspase 3 pathway and anti-inflammatory responses.},
  author={Yun-Qi Xu and Ling Long and Jun-Qiang Yan and Lei Wei and Meng-Qiu Pan and Hui-min Gao and P Zhou and Mei Liu and Can-sheng Zhu and Bei-sha Tang and Qing Wang},
  journal={CNS neuroscience & therapeutics},
  year={2013},
  volume={19 3},
  pages={170-7}
}
BACKGROUND In addition to their original applications for lowering cholesterol, statins display multiple neuroprotective effects. Inflammatory reactions and the PI3K/AKT/caspase 3 pathway are strongly implicated in dopaminergic neuronal death in Parkinson's disease (PD). This study aims to investigate how simvastatin affects 6-hydroxydopamine-lesioned PC12 via regulating PI3K/AKT/caspase 3 and modulating inflammatory mediators. METHODS 6-hydroxydopamine-treated PC12 cells were used to… CONTINUE READING
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