Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection.

@article{Lee2004SimvastatinIH,
  title={Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection.},
  author={Tzong-Shyuan Lee and Chih-Chieh Chang and Yi Zhu and John Shyy},
  journal={Circulation},
  year={2004},
  volume={110 10},
  pages={
          1296-302
        }
}
BACKGROUND Evidence from experimental and clinical studies indicates that statins can protect the vessel wall through cholesterol-independent mechanisms. The "pleiotropic" effects include the prevention of inflammation and proliferation of vascular cells. Here, we studied whether heme oxygenase-1 (HO-1), an important cytoprotective molecule, is induced by simvastatin and the role of HO-1 in the pleiotropic effects of simvastatin. METHODS AND RESULTS Human and rat aortic smooth muscle cells… CONTINUE READING

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