Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells.

@article{Takeda2007SimvastatinIB,
  title={Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells.},
  author={Ikuko Takeda and Shin-ichiro Maruya and Takashi Shirasaki and Hiroki Mizukami and Takenori Takahata and Jeffrey N. Myers and Seiji Kakehata and Soroku Yagihashi and Hideichi Shinkawa},
  journal={Cancer science},
  year={2007},
  volume={98 6},
  pages={890-9}
}
The 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors, also called statins, are commonly used as lipid-lowering drugs that inhibit cholesterol biosynthesis. An anticancer effect, as a pleiotropic function of certain statins, has been hypothesized. In the present study, we investigated the effect of simvastatin, one of the natural statins, on cell proliferation, cell cycle, invasive activity, and molecular expressions associated with cell-extracellular matrix adhesion, signal… CONTINUE READING
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