Simvastatin in the acute phase of ischemic stroke: a safety and efficacy pilot trial.

@article{Montaner2008SimvastatinIT,
  title={Simvastatin in the acute phase of ischemic stroke: a safety and efficacy pilot trial.},
  author={J Montaner and Pilar Chac{\'o}n and Jerzy Krupinski and Francisco Rubio and Monica Millan and Carlos Alberto Molina and Pilar Hereu and Manuel de la Quintana and Jos{\'e} Alvarez-Sab{\'i}n},
  journal={European journal of neurology},
  year={2008},
  volume={15 1},
  pages={82-90}
}
Although statins are being used for secondary prevention of ischemic stroke, recent experimental data have shown new pleiotropic effects of these drugs responsible for their role in neuroprotection. We conducted a pilot, double-blind, randomized, multicenter clinical trial to study for the first time safety and efficacy of simvastatin in the acute phase of ischemic stroke. Simvastatin/placebo was given at 3-12 h from symptom onset to 60 patients with cortical strokes. Efficacy on the evolution… CONTINUE READING