Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2.

@article{Tuomisto2008SimvastatinHA,
  title={Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2.},
  author={Tiina T Tuomisto and Henri Lumivuori and Emilia Kansanen and S H H{\"a}kkinen and Mikko Petri Turunen and Johannes V. van Thienen and Anton J. G. Horrevoets and A L Levonen and Seppo Yl{\"a}-Herttuala},
  journal={Cardiovascular research},
  year={2008},
  volume={78 1},
  pages={175-84}
}
AIMS Statins have beneficial vascular effects beyond their cholesterol-lowering action. Since macrophages play a central role in atherogenesis, we characterized the effects of simvastatin on gene expression profile of human peripheral blood monocyte (HPBM)-macrophages. METHODS AND RESULTS Gene expression profile was studied using Affymetrix gene chip analysis. Lentiviral gene transfer of Kruppel-like factor 2 (KLF-2) was used to further study its role in macrophages. Simvastatin treatment… CONTINUE READING
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