Simvastatin exhibits antiproliferative effects on spheres derived from canine mammary carcinoma cells.

@article{Torres2015SimvastatinEA,
  title={Simvastatin exhibits antiproliferative effects on spheres derived from canine mammary carcinoma cells.},
  author={Cristian Gabriel Torres and Araceli Olivares and Caroll Stoore},
  journal={Oncology reports},
  year={2015},
  volume={33 5},
  pages={
          2235-44
        }
}
Mammary cancer is the most frequent type of tumor in the female canine. Treatments are mainly limited to surgery and chemotherapy; however, these tumors may develop clinical recurrence, metastasis and chemoresistance. The existence of a subpopulation of cancer cells with stemness features called cancer stem-like cells, may explain in part these characteristics of tumor progression. The statins, potent blockers of cholesterol synthesis, have also shown antitumor effects on cancer mammary cells… CONTINUE READING

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