Simvastatin enhances bone morphogenetic protein receptor type II expression.

  title={Simvastatin enhances bone morphogenetic protein receptor type II expression.},
  author={Hong Hui Hu and Arthur Sung and Guohua Zhao and Lingfang Shi and Daoming Qiu and Toshihiko Nishimura and Peter N Kao},
  journal={Biochemical and biophysical research communications},
  volume={339 1},
Statins confer therapeutic benefits in systemic and pulmonary vascular diseases. Bone morphogenetic protein (BMP) receptors serve essential signaling functions in cardiovascular development and skeletal morphogenesis. Mutations in BMP receptor type II (BMPR2) are associated with human familial and idiopathic pulmonary arterial hypertension, and pathologic neointimal proliferation of vascular endothelial and smooth muscle cells within small pulmonary arteries. In severe experimental pulmonary… CONTINUE READING
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