Simvastatin decreases steroid production in the H295R cell line and decreases steroids and FSH in female rats.

@article{Guldvang2015SimvastatinDS,
  title={Simvastatin decreases steroid production in the H295R cell line and decreases steroids and FSH in female rats.},
  author={Anna Guldvang and Cecilie Hurup Hansen and Johan Juhl Weisser and Bent Halling‐S{\o}rensen and Bjarne Styrishave},
  journal={Reproductive toxicology},
  year={2015},
  volume={58},
  pages={
          174-83
        }
}
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15 Citations
Background Citations
5
Methods Citations
1
Results Citations
1

15 Citations

Atorvastatin decreases steroid production in H295R cells and in major endocrine tissues of male rats
TLDR
Overall, ATO exerted pronounced effects on steroid production both in vitro and in vivo at therapeutically relevant doses, which clearly demonstrates the high potency of ATO to affect steroid homeostasis during therapeutic treatment.
Toxic effects of triptolide on adrenal steroidogenesis in H295R cells and female rats
TLDR
Corticosteroid may be a potential biomarker for the treatment of multiorgan toxicity of TP, as it significantly decreased the level of cortisol in H295R cells and thelevel of plasma corticosterone in both normal and CIA rats.
Rosuvastatin exposure in female Wistar rats alters uterine contractility and do not show evident (anti)estrogenic effects.
TLDR
Rosuvastatin can affect uterine physiology not necessarily by an endocrine mechanism related to the estrogen signaling, but possibly by its pleiotropic effects, with indirect tissue and cellular interactions, since in vivo and ex vivo exposures of uterine fragments to rosuvastatin presented different responses in uterine contractile parameters, which require further studies upon the precise mechanism of action of this drug in female reproductive function.
Enantioselective endocrine disrupting effects of omeprazole studied in the H295R cell assay and by molecular modeling.
The use of purified rat Leydig cells complements the H295R screen to detect chemical-induced alterations in testosterone production†
TLDR
The greater dynamic range of testosterone production in a primary rat Leydig cell assay permitted detection of chemical-induced testosterone inhibition that was not detected by the high-throughput screening format of the H295R steroidogenesis assay.
Potentiation of mitotane action by rosuvastatin: New insights for adrenocortical carcinoma management.
Mitotane (also termed o,p'‑DDD) is the most effective therapy for advanced adrenocortical carcinoma (ACC). Mitotane‑induced dyslipidemia is treated with statins. Mitotane and statins are known to…
The six most widely used selective serotonin reuptake inhibitors decrease androgens and increase estrogens in the H295R cell line.
Statins inhibit blastocyst formation by preventing geranylgeranylation.
TLDR
In preimplantation development, statins may act through HIPPO pathway to interfere with trophectoderm specification and thereby inhibit blastocyst formation, which indicates that HMG-CoA reductase activity is required for blastocySt formation mainly through the production of GGPP but not cholesterol.
Two simple cleanup methods combined with LC-MS/MS for quantification of steroid hormones in in vivo and in vitro assays
TLDR
A novel method was developed for the determination of 14 steroids in the H295R in vitro assay without the need for solid phase extraction (SPE) purification prior to LC-MS2 analysis, which fulfills the recommendations for the H 295R assay suggested by the OECD.
Occurrence, removal and risk assessment of steroid hormones in two wastewater stabilization pond systems in Morogoro, Tanzania.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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