Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats.

@article{GiustiPaiva2004SimvastatinDN,
  title={Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats.},
  author={Alexandre Giusti-Paiva and Maria Regina Martinez and Jorge Vinicius Cestari Felix and Maria Jos{\'e} Alves da Rocha and Evelin Capellari C{\'a}rnio and Lucila L K Elias and Jos{\'e} Antunes-Rodrigues},
  journal={Shock},
  year={2004},
  volume={21 3},
  pages={271-5}
}
Lipopolysaccharides (LPS) can be used to induce experimental endotoxic shock, which is characterized by a significant decrease in mean arterial pressure (MAP) and a decreased vasoconstrictor response that have been attributed to excessive nitric oxide production. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), in addition to lowering serum cholesterol levels, exert many pleiotropic effects, including anti-inflammatory action. In the present study, we… CONTINUE READING

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