Simvastatin decreases invasiveness of human endometrial stromal cells.

  title={Simvastatin decreases invasiveness of human endometrial stromal cells.},
  author={Anna Sokalska and Amanda B Cress and Kaylon L. Bruner-Tran and Kevin G. Osteen and Hugh S. Taylor and Israel Ortega and Antoni J. Duleba},
  journal={Biology of reproduction},
  volume={87 1},
  pages={2, 1-6}
Recently we reported that statins, the competitive inhibitors of the key enzyme regulating the mevalonate pathway, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), decrease proliferation of human endometrial stromal (HES) cells. Furthermore, we found that simvastatin treatment reduces the number and the size of endometrial implants in a nude mouse model of endometriosis. The present study was undertaken to investigate the effect of simvastatin on HES cell invasiveness and on expression… CONTINUE READING


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