Simvastatin decreases IL-6 and IL-8 production in epithelial cells.

  title={Simvastatin decreases IL-6 and IL-8 production in epithelial cells.},
  author={Kenji Sakoda and Masafumi Yamamoto and Yoichi Negishi and James K. Liao and Koichi Node and Yuichi Izumi},
  journal={Journal of dental research},
  volume={85 6},
Many cardiovascular studies have suggested that 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitors (statins) have anti-inflammatory effects independent of cholesterol lowering. As a chronic inflammatory disease, periodontitis shares some mechanisms with atherosclerosis. Since oral epithelial cells participate importantly in periodontal inflammation, we measured simvastatin effects on interleukin-6 and interleukin-8 production by cultured human epithelial cell line (KB cells) in… CONTINUE READING


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