Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase.

@article{Sugawara2008SimvastatinAO,
  title={Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase.},
  author={Takashi Sugawara and Robert Ayer and Vikram R. Jadhav and Wanqiu Chen and Tamiji Tsubokawa and John H Zhang},
  journal={Journal of neuroscience research},
  year={2008},
  volume={86 16},
  pages={
          3635-43
        }
}
The mechanisms involved in simvastatin-mediated attenuation of cerebral vasospasm after subarachnoid hemorrhage (SAH) are unclear. We investigated the role of the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway and endothelial nitric oxide synthase (eNOS) in the cerebral vasculature in statin-mediated attenuation of cerebral vasospasm using wortmannin, an irreversible pharmacological PI3K inhibitor, and a rat SAH endovascular perforation model. Simvastatin was administered… CONTINUE READING

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