Simvastatin attenuates renal inflammation, tubular transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction.

José M. N. Vieira, Eduardo Mantovani, +4 authors Roberto Zatz
Published 2005 in
Nephrology, dialysis, transplantation : official…

Abstract

BACKGROUND The pleiotropic actions of statins have been largely explored. These drugs have been tested in several models of progressive renal disease, most of them accompanied by hypertension. We sought to investigate more closely the effects of simvastatin on renal interstitial fibrosis due to unilateral ureteral obstruction (UUO). METHODS Munich-Wistar… (More)

Effect of Angiotensin II and Small GTPase Ras Signaling Pathway Inhibition on Early Renal Changes in a Murine Model of Obstructive Nephropathy

Ana B. Rodríguez-Peña, Isabel Fuentes-Calvo, +5 authors José M. López-Novoa
BioMed research international
2014

Simvastatin attenuates renal inflammation, tubular transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction.

Abstract

Topics

7 Figures and Tables

Cited By

The Effect of Statin on Epithelial-Mesenchymal Transition in Peritoneal Mesothelial Cells

Indoleamine 2, 3-dioxygenase (IDO) increases during renal fibrogenesis and its inhibition potentiates TGF-β 1-induced epithelial to mesenchymal transition

Simvastatin Attenuates Renal Failure in Mice with a 5/6 Subtotal Nephrectomy

Amelioration of Renal Inflammation, Endoplasmic Reticulum Stress and Apoptosis Underlies the Protective Effect of Low Dosage of Atorvastatin in Gentamicin-Induced Nephrotoxicity

Association of statin use and the risk of end-stage renal disease: A nationwide Asian population-based case-control study.

Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy

Simvastatin ameliorates experimental autoimmune encephalomyelitis by inhibiting Th1/Th17 response and cellular infiltration

Effect of Angiotensin II and Small GTPase Ras Signaling Pathway Inhibition on Early Renal Changes in a Murine Model of Obstructive Nephropathy

Role of WNT10A-Expressing Kidney Fibroblasts in Acute Interstitial Nephritis

Rotenone Remarkably Attenuates Oxidative Stress, Inflammation, and Fibrosis in Chronic Obstructive Uropathy

References

Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention.

Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells.

Effect of combining ACE inhibitor and statin in severe experimental nephropathy.

The single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction: twenty-something years on

Natural history, risk factors, and impact of subclinical rejection in kidney transplantation.

Pravastatin treatment attenuates interstitial inflammation and fibrosis in a rat model of chronic cyclosporine-induced nephropathy.

DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition.

HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats.

HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells.

Evidence that fibroblasts derive from epithelium during tissue fibrosis.

Slides referencing similar topics

Simvastatin attenuates renal inflammation, tubular transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction.

Abstract

Topics

7 Figures and Tables

Cited By

The Effect of Statin on Epithelial-Mesenchymal Transition in Peritoneal Mesothelial Cells

Indoleamine 2, 3-dioxygenase (IDO) increases during renal fibrogenesis and its inhibition potentiates TGF-β 1-induced epithelial to mesenchymal transition

Simvastatin Attenuates Renal Failure in Mice with a 5/6 Subtotal Nephrectomy

Amelioration of Renal Inflammation, Endoplasmic Reticulum Stress and Apoptosis Underlies the Protective Effect of Low Dosage of Atorvastatin in Gentamicin-Induced Nephrotoxicity

Association of statin use and the risk of end-stage renal disease: A nationwide Asian population-based case-control study.

Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy

Simvastatin ameliorates experimental autoimmune encephalomyelitis by inhibiting Th1/Th17 response and cellular infiltration

Effect of Angiotensin II and Small GTPase Ras Signaling Pathway Inhibition on Early Renal Changes in a Murine Model of Obstructive Nephropathy

Role of WNT10A-Expressing Kidney Fibroblasts in Acute Interstitial Nephritis

Rotenone Remarkably Attenuates Oxidative Stress, Inflammation, and Fibrosis in Chronic Obstructive Uropathy

References

Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention.

Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells.

Effect of combining ACE inhibitor and statin in severe experimental nephropathy.

The single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction: twenty-something years on

Natural history, risk factors, and impact of subclinical rejection in kidney transplantation.

Pravastatin treatment attenuates interstitial inflammation and fibrosis in a rat model of chronic cyclosporine-induced nephropathy.

DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition.

HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats.

HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells.

Evidence that fibroblasts derive from epithelium during tissue fibrosis.

Similar Papers

Slides referencing similar topics