Simvastatin attenuates oxidant-induced mitochondrial dysfunction in cardiac myocytes.

@article{Jones2003SimvastatinAO,
  title={Simvastatin attenuates oxidant-induced mitochondrial dysfunction in cardiac myocytes.},
  author={Steven P Jones and Yasushi Teshima and Masaharu Akao and Eduardo Marb{\'a}n},
  journal={Circulation research},
  year={2003},
  volume={93 8},
  pages={697-9}
}
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can exert beneficial effects independently of serum cholesterol reduction by increasing the bioavailability of nitric oxide. However, it is unclear whether statins can exert such effects directly on cardiac myocytes and whether mitochondria are potential targets. Neonatal rat cardiac myocytes were cultured and subjected to oxidant stress (1 hour of 100 micromol/L H2O2). Mitochondrial membrane potential, a key… CONTINUE READING
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