Simvastatin attenuates bleomycin-induced pulmonary fibrosis in mice.

@article{Ou2008SimvastatinAB,
  title={Simvastatin attenuates bleomycin-induced pulmonary fibrosis in mice.},
  author={Xue-mei Ou and Yulin Feng and Fu-qiang Wen and Xiang-yang Huang and Jun Xiao and Ke Wang and Tao Wang},
  journal={Chinese medical journal},
  year={2008},
  volume={121 18},
  pages={1821-9}
}
BACKGROUND Bleomycin-induced fibrosis is extensively used to model aspects of the pathogenesis of interstitial pulmonary fibrosis. This study aimed to determine the benefic effects and mechanisms of simvastatin on bleomycin-induced pulmonary fibrosis in mice. METHODS Bleomycin-induced pulmonary fibrosis mice were administered with simvastatin in different doses for 28 days. We measured inflammatory response, fibrogenic cytokines and profibrogenic markers in both bleomycin-stimulated and… CONTINUE READING
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