Simvastatin and sildenafil combine to attenuate pulmonary hypertension.

@article{Zhao2009SimvastatinAS,
  title={Simvastatin and sildenafil combine to attenuate pulmonary hypertension.},
  author={Lan Zhao and Abdelkrim Sebkhi and Omer Ali Mohamed Ali and Beata W{\'o}jciak-Stothard and Lira Mamanova and Quan-yu Yang and John Wharton and Martin R. Wilkins},
  journal={The European respiratory journal},
  year={2009},
  volume={34 4},
  pages={
          948-57
        }
}
Statins have been proposed to be a potential treatment for pulmonary arterial hypertension. If introduced into clinical practice, the statin would have to be used in conjunction with established therapy. We investigated the effects of combining simvastatin with a phosphodiesterase type-5 inhibitor, sildenafil, in the rat model of hypoxia-induced pulmonary hypertension. Rats were allocated to either: 1) a prevention protocol, to receive simvastatin 20 mg x kg(-1) x day(-1) by intraperitoneal… CONTINUE READING

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