Simvastatin and rosuvastatin mobilize Endothelial Progenitor Cells but do not prevent their acute decrease during systemic inflammation.

@article{Spiel2008SimvastatinAR,
  title={Simvastatin and rosuvastatin mobilize Endothelial Progenitor Cells but do not prevent their acute decrease during systemic inflammation.},
  author={Alexander O. Spiel and Florian B. Mayr and Judith Maria Leitner and Christa Firbas and Wolfgang Sieghart and Bernd Jilma},
  journal={Thrombosis research},
  year={2008},
  volume={123 1},
  pages={108-13}
}
INTRODUCTION Endothelial Progenitor Cells (EPCs) are a specific subtype of haematopoietic stem cells that contribute to the repair of injured endothelium. Treatment with atorvastatin has been shown to increase EPC counts in patients with stable coronary artery disease. Numbers of circulating EPCs decrease in various inflammatory diseases. Thus, we hypothesized that short term statin pre-treatment may alter the acute change in EPC levels during systemic inflammation. OBJECTIVES To explore the… CONTINUE READING