Simvastatin and oxidative stress in humans: A randomized, double-blinded, placebo-controlled clinical trial

Abstract

Simvastatin reduces the blood concentration of cholesterol by inhibiting hydroxymethylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis, and thereby reduces the risk of cardiovascular disease. In addition, simvastatin treatment leads to a reduction in fluxes in mitochondrial respiratory complexes I and II and might thereby… (More)
DOI: 10.1016/j.redox.2016.05.007

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Cite this paper

@inproceedings{Rasmussen2016SimvastatinAO, title={Simvastatin and oxidative stress in humans: A randomized, double-blinded, placebo-controlled clinical trial}, author={Sanne Tofte Rasmussen and Jon Tr{\ae}rup Andersen and Torben Kj{\ae}r Nielsen and Vanja Cejvanovic and Kasper Meidahl Petersen and T Brink Henriksen and Allan Weimann and Jens Lykkesfeldt and Henrik Enghusen Poulsen}, booktitle={Redox biology}, year={2016} }