Simvastatin and bezafibrate: Effects on serum lipoproteins and lecithin: Cholesterol acyltransferase activity in familial hypercholesterolaemia

@article{Weisweiler1988SimvastatinAB,
  title={Simvastatin and bezafibrate: Effects on serum lipoproteins and lecithin: Cholesterol acyltransferase activity in familial hypercholesterolaemia},
  author={P. Weisweiler},
  journal={European Journal of Clinical Pharmacology},
  year={1988},
  volume={35},
  pages={579-583}
}
Sixteen subjects with familial hypercholesterolaemia were randomly assigned to treatment with simvastatin 20–40 mg/day (an inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase) or with bezafibrate 600 mg/day (a clofibrate analogue) for 12 weeks. Both drugs produced significant reductions in serum and LDL cholesterol; mean percentage fall −30.5% and −38.1% (simvastatin) and −17.8% and −20.6% (bezafibrate), respectively. Both drugs also caused a decrease in VLDL cholesterol, while only… CONTINUE READING
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