Simvastatin and atorvastatin attenuate VCAM-1 and uPAR expression on human endothelial cells and platelet surface expression of CD40 ligand.

@article{Stach2012SimvastatinAA,
  title={Simvastatin and atorvastatin attenuate VCAM-1 and uPAR expression on human endothelial cells and platelet surface expression of CD40 ligand.},
  author={Ksenija Stach and Xuan Duc Nguyen and Siegfried Lang and Elif Elmas and Christel Weiss and Martin Borggrefe and Joachim Fischer and Thorsten K{\"a}lsch},
  journal={Cardiology journal},
  year={2012},
  volume={19 1},
  pages={20-8}
}
BACKGROUND In addition to their cholesterol lowering ability, statins have proven pleiotropic effects in the cardiovascular system. Chronic inflammation with interactions between platelets and endothelial cells leads to an upregulation of activity markers of atherosclerosis. The purpose of this study was to investigate the effects of simvastatin and atorvastatin on platelets and endothelial cells in an in vitro endothelial cell model. METHODS AND RESULTS After a 24 h incubation period with… CONTINUE READING
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