Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway.

@article{Wolfrum2004SimvastatinAR,
  title={Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway.},
  author={Sebastian Wolfrum and Andreas Dendorfer and Morten Schutt and Britta Weidtmann and Angelika Heep and Klaus Tempel and Hermann H. Klein and Peter Dominiak and Gert Richardt},
  journal={Journal of cardiovascular pharmacology},
  year={2004},
  volume={44 3},
  pages={
          348-55
        }
}
Long-term pretreatment with statins reduces myocardial injury after acute ischemia and reperfusion by increasing the expression of endothelial nitric oxide synthase (eNOS). We hypothesized that statins may act rapidly enough to protect the myocardium from ischemia/reperfusion injury when given right at the beginning of the reperfusion period and tried to delineate the role of PI 3-kinase/Akt pathway in early eNOS activation. Activated simvastatin was given intravenously 3 minutes before… CONTINUE READING
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