Simvastatin Protects Neurons from Cytotoxicity by Up-regulating Bcl-2 mRNA and Protein: The Role of Endothelin-1 on Bcl-2 Expression

@inproceedings{Wood2007SimvastatinPN,
  title={Simvastatin Protects Neurons from Cytotoxicity by Up-regulating Bcl-2 mRNA and Protein: The Role of Endothelin-1 on Bcl-2 Expression},
  author={William G. Wood and Tammy A. Butterick and Leslie N. Johnson-Anuna and Gunter P Eckert and Urule Igbavboa and Walter E. Mueller},
  year={2007}
}
Statins are most commonly prescribed to reduce hypercholesterolemia; however, recent studies have shown that statins have additional benefits, including neuroprotection. Until now, the mechanism underlying statin-induced neuroprotection has been poorly understood. Recent in vivo studies from our lab reported the novel finding that simvastatin increased expression levels of a gene encoding for a major cell survival protein, bcl-2 [Johnson-Anuna et al., J. Pharmacol. Exp. Ther. 312 (2005) 786… CONTINUE READING