Simvastatin Attenuates Intestinal Fibrosis Independent of the Anti-Inflammatory Effect by Promoting Fibroblast/Myofibroblast Apoptosis in the Regeneration/Healing Process from TNBS-Induced Colitis

@article{Abe2011SimvastatinAI,
  title={Simvastatin Attenuates Intestinal Fibrosis Independent of the Anti-Inflammatory Effect by Promoting Fibroblast/Myofibroblast Apoptosis in the Regeneration/Healing Process from TNBS-Induced Colitis},
  author={Yosuke Abe and Mitsuyuki Murano and Naoko Murano and Eijiro Morita and Takuya K Inoue and Ken Kawakami and Kumi Ishida and Takanori Kuramoto and Kazuki Kakimoto and Toshihiko Okada and Ken Narabayashi and Eiji Umegaki and Kazuhide Higuchi},
  journal={Digestive Diseases and Sciences},
  year={2011},
  volume={57},
  pages={335-344}
}
Intestinal deformity and stenosis are induced by fibrosis during the process healing of intestinal chronic inflammation in inflammatory bowel disease (IBD). Potent anti-inflammatory treatment of patients with Crohn’s disease (CD) may induce fibrous stenosis, and this is often difficult to treat in clinical practice. Therefore, it is necessary to develop a treatment strategy that concomitantly exhibits repair/regenerative and anti-fibrotic effects, in addition to the current anti-inflammatory… CONTINUE READING
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