Simvastatin Action Is Not Related to HDAC 2 Expression in Non-Small Cell Lung Cancer ( NSCLC )

@inproceedings{Luca2016SimvastatinAI,
  title={Simvastatin Action Is Not Related to HDAC 2 Expression in Non-Small Cell Lung Cancer ( NSCLC )},
  author={Gallelli Luca and Falcone Daniela and Perri Mariarita and Erika Cione and Pelaia Girolamo and Mesuraca Maria and Terracciano Rosa and Spaziano Giuseppe and D. Bruno and Navarra Michele and Savino Rocco},
  year={2016}
}
  • Gallelli Luca, Falcone Daniela, +8 authors Savino Rocco
  • Published 2016
In this study, we lowered the expression of HDAC2 protein, to evaluate the effects of simvastatin on the biochemical pathways involved in inflammatory and metastatic response. The model used is the non-small cell lung cancer line (GLC-82). Trypan blue staining for assessing vital cell number to be seed and MTT assay was used as cell proliferation test. Lentivus for HDAC2 was used to silence its mRNA. Western blotting analysis was used for protein extracts, and ELISA was done on culture media… CONTINUE READING