Simvastatin, Sildenafil and Their Combination in Monocrotaline Induced Pulmonary Arterial Hypertension

@inproceedings{Lee2010SimvastatinSA,
  title={Simvastatin, Sildenafil and Their Combination in Monocrotaline Induced Pulmonary Arterial Hypertension},
  author={Dong Seok Lee and Yung Kyu Kim and Yong Wook Jung},
  booktitle={Korean circulation journal},
  year={2010}
}
BACKGROUND AND OBJECTIVES Pulmonary arterial hypertension (PAH) is a life threatening disease characterized by progressive pulmonary arterial occlusion which may ultimately result in death. Currently, the available treatments are diverse, but no therapy alone can reverse the disease process although they may have some clinical benefits. This study was designed to investigate single and combination therapy of simvastatin and sildenafil, which have different mechanisms of action, in monocrotaline… CONTINUE READING

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