Simultaneously Increased TxA2 Activity in Isolated Arterioles and Platelets of Rats With Hyperhomocysteinemia

@inproceedings{ZoltanUngvari2000SimultaneouslyIT,
  title={Simultaneously Increased TxA2 Activity in Isolated Arterioles and Platelets of Rats With Hyperhomocysteinemia},
  author={ZoltanUngvari and EszterSarkadi-Nagy and ZsoltBagi and LajosSzollár and AkosKoller},
  year={2000}
}
Abstract—We aimed to elucidate the effect of hyperhomocysteinemia (HHcy) on the synthesis of prostaglandins in rat skeletal muscle arterioles and platelets. Male Wistar rats were divided into 2 groups: (1) control rats, with plasma Hcy levels of 6.5±0.5 μmol/L (n=50) and (2) rats with HHcy, induced by daily intake of 1 g/kg body weight methionine in the drinking water for 4 weeks (plasma Hcy levels were 20.6±3.0 μmol/L, P<0.01 versus controls; n=50). Arterioles (diameter ≈130 μm) were isolated… CONTINUE READING

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Cardiovascular pathogenesis in hyperhomocysteinemia.

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  • 2008
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