Simultaneous vs. Sequential Analysis for Population PK/PD Data I: Best-Case Performance

@article{Zhang2003SimultaneousVS,
  title={Simultaneous vs. Sequential Analysis for Population PK/PD Data I: Best-Case Performance},
  author={Liping Zhang and Stuart L. Beal and Lewis B. Sheiner},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
  year={2003},
  volume={30},
  pages={387-404}
}
Dose [-concentration]-effect relationships can be obtained by fitting a predictive pharmacokinetic (PK)-pharmacodynamic (PD) model to both concentration and effect observations. Either a model can be fit simultaneously to all the data (“simultaneous” method), or first a model can be fit to the PK data and then a model can be fit to the PD data, conditioning in some way on the PK data or on the estimates of the PK parameters (“sequential” method). Using simulated data, we compare the performance… CONTINUE READING
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