Simultaneous suppression of Src and signal transducer and activator of transcription 3 inhibits the growth of epithelial ovarian cancer cells.

@article{Lee2013SimultaneousSO,
  title={Simultaneous suppression of Src and signal transducer and activator of transcription 3 inhibits the growth of epithelial ovarian cancer cells.},
  author={Shin-Wha Lee and Jin Taek Yoo and Soo-Hyoung Lee and Dong Wook Kim and Yong Man Kim and Young-Tak Kim},
  journal={European journal of obstetrics, gynecology, and reproductive biology},
  year={2013},
  volume={169 1},
  pages={75-9}
}
OBJECTIVE The reciprocal regulation of c-Src and STAT3 activation seems to be associated with the poor response to c-Src inhibitors of ovarian cancer. This study aims to investigate inhibition of cell proliferation and enhancement of the cytotoxic effect of chemotherapeutic agents via simultaneous suppression of c-Src and STAT3 in ovarian cancer cell lines. STUDY DESIGN Specific siRNAs targeting c-Src and STAT3 were produced and transfected into an SKOV3 ovarian cancer cell line. We confirmed… CONTINUE READING