Simultaneous screening and quantitation of 18 antihistamine drugs in blood by liquid chromatography ionspray tandem mass spectrometry.

@article{Gergov2001SimultaneousSA,
  title={Simultaneous screening and quantitation of 18 antihistamine drugs in blood by liquid chromatography ionspray tandem mass spectrometry.},
  author={Merja Gergov and J. N. Robson and Ilkka Ojanper{\"a} and Olli Heinonen and Erkki Vuori},
  journal={Forensic science international},
  year={2001},
  volume={121 1-2},
  pages={108-15}
}
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method is presented for the simultaneous screening and quantitation of 18 antihistamine drugs in blood samples. Sample pretreatment involved liquid-liquid extraction of the basic antihistamines followed by a second extraction of the acidic antihistamines. The recoveries were 43-113% for basic drugs and 23-66% for acidic drugs. The combined extracts were run by LC on C(18) reversed phase column using acetonitrile-ammonium acetate mobile… CONTINUE READING
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