Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2.

@article{Sabino2002SimultaneousRI,
  title={Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2.},
  author={Mary Ann C. Sabino and Joseph R. Ghilardi and Joost L M Jongen and Cathy P. Keyser and Nancy M. Luger and David B. Mach and Christopher M. Peters and Scott D. Rogers and Matthew J. Schwei and Carmen de Felipe and Patrick W Mantyh},
  journal={Cancer research},
  year={2002},
  volume={62 24},
  pages={7343-9}
}
More than half of all chronic cancer pain arises from metastases to bone, and bone cancer pain is one of the most difficult of all persistent pain states to fully control. Several tumor types including sarcomas and breast, prostate, and lung carcinomas grow in or preferentially metastasize to the skeleton where they proliferate, and induce significant bone remodeling, bone destruction, and cancer pain. Many of these tumors express the isoenzyme cycloxygenase-2 (COX-2), which is involved in the… CONTINUE READING
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