Simultaneous quantitative monitoring of drug-induced caspase cascade pathways in carcinoma cells.

@article{Naoghare2010SimultaneousQM,
  title={Simultaneous quantitative monitoring of drug-induced caspase cascade pathways in carcinoma cells.},
  author={Pravin K. Naoghare and Hyeon A Ki and Seung-Mann Paek and Yu Kyung Tak and Young-Ger Suh and Sang Geon Kim and Kyeong-Hee Lee and Joon Myong Song},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2010},
  volume={2 1},
  pages={
          46-57
        }
}
Caspases are the key mediators of apoptosis. The caspase cascade includes a series of events leading to the activation of initiator and downstream caspases in a cell. Analysis of the caspase cascade in intact cells, however, has generally been limited as the simultaneous monitoring of upstream and downstream caspases is not well executed. In an effort to monitor the activation of caspase cascades in an intact cell, high-content cellular imaging that allows simultaneous quantitative monitoring… CONTINUE READING