Simultaneous quantitative assay of phenobarbital, phenytoin, and p-hydroxydiphenylhydantoin by HPLC and a comparison with EMIT.


The antiepileptic drugs, phenobarbital and phenytoin, were determined in plasma by enzyme immunoassay (EMIT) and by high-pressure liquid chromatography (HPLC). In addition, the major metabolite of phenytoin, p-hydroxydiphenylhydantoin (HPPH), was determined by HPLC. Within-day and between-day coefficients of variation for both methods were 7.6% or less for… (More)


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