Simultaneous quantitative analysis of mebendazole polymorphs A-C in powder mixtures by DRIFTS spectroscopy and ANN modeling.

@article{Kachrimanis2010SimultaneousQA,
  title={Simultaneous quantitative analysis of mebendazole polymorphs A-C in powder mixtures by DRIFTS spectroscopy and ANN modeling.},
  author={Kyriakos Kachrimanis and M Rontogianni and Stavros Malamataris},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2010},
  volume={51 3},
  pages={512-20}
}
In the present study, a simple method, based on diffuse reflectance FTIR spectroscopy (DRIFTS) and artificial neural network (ANN) modeling is developed for the simultaneous quantitative analysis of mebendazole polymorphs A-C in powder mixtures. Spectral differences between the polymorphs are elucidated by computationally assisted band assignments on the basis of quantum chemical calculations, and subsequently, the spectra are preprocessed by calculation of 1st and 2nd derivatives. Then ANN… CONTINUE READING