Simultaneous quantitative analysis of letrozole, its carbinol metabolite, and carbinol glucuronide in human plasma by LC-MS/MS.

@article{Precht2012SimultaneousQA,
  title={Simultaneous quantitative analysis of letrozole, its carbinol metabolite, and carbinol glucuronide in human plasma by LC-MS/MS.},
  author={Jana C Precht and Boian Ganchev and Georg Heinkele and Hiltrud Brauch and Matthias Schwab and Thomas E M{\"u}rdter},
  journal={Analytical and bioanalytical chemistry},
  year={2012},
  volume={403 1},
  pages={301-8}
}
Letrozole is an efficient endocrine treatment of postmenopausal breast cancer, however, not all patients benefit from this treatment, and moreover, severe side-effects like arthralgia frequently lead to discontinuation. To better understand inter-individual variability in drug response and side-effects, plasma analysis of steady-state concentrations of letrozole and its major metabolites is crucial. We developed a rapid, sensitive, and specific method for the simultaneous quantification of… CONTINUE READING

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