Simultaneous quantification of multiple classes of phenolic compounds in blood plasma by liquid chromatography-electrospray tandem mass spectrometry.

@article{Chang2010SimultaneousQO,
  title={Simultaneous quantification of multiple classes of phenolic compounds in blood plasma by liquid chromatography-electrospray tandem mass spectrometry.},
  author={Hong Chang and Yi Wan and Jonathan E. Naile and Xiaowei Zhang and Steve B. Wiseman and Markus Hecker and Michael Hon-Wah Lam and John Paul Giesy and Paul D. A. Jones},
  journal={Journal of chromatography. A},
  year={2010},
  volume={1217 4},
  pages={506-13}
}
A method using high performance liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS) in positive ion mode was developed for the simultaneous analysis of 30 phenolic compounds, including four estrogens, bisphenol A (BPA), 10 hydroxylated polybrominated dephenyl ethers (OH-PBDEs) and 15 bromophenols (BRPs), in blood plasma. In the present method, derivatization with dansyl chloride was employed, and all the derivertized target compounds were well resolved on a 100mm Xbridge… CONTINUE READING
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