Simultaneous quantification of loxapine, loxapine N-oxide, amoxapine, 8-hydroxyloxapine and 7-hydroxyloxapine in human plasma using LC-MS/MS.

@article{Meng2017SimultaneousQO,
  title={Simultaneous quantification of loxapine, loxapine N-oxide, amoxapine, 8-hydroxyloxapine and 7-hydroxyloxapine in human plasma using LC-MS/MS.},
  author={M. Meng and N. Zhao and Carrie C Pederson and Edward A. Harrison and Charisse Green and S. Gorman and S. Reuschel},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2017},
  volume={1046},
  pages={
          87-97
        }
}
  • M. Meng, N. Zhao, +4 authors S. Reuschel
  • Published 2017
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • Loxapine is an antipsychotic medication used for the treatment of schizophrenia. In vivo, loxapine is metabolized to multiple metabolites. A high performance liquid chromatographic-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of loxapine and 4 of its metabolites, loxapine N-oxide, amoxapine (N-desmethyl loxapine), 8-hydroxyloxapine and 7-hydroxyloxapine, in human plasma to support regulated clinical development. During method development… CONTINUE READING
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