Simultaneous quantification of loxapine, loxapine N-oxide, amoxapine, 8-hydroxyloxapine and 7-hydroxyloxapine in human plasma using LC-MS/MS.

M. Meng; N. Zhao; Carrie C Pederson; Edward A. Harrison; Charisse Green; S. Gorman; S. Reuschel

DOI:10.1016/j.jchromb.2017.01.007

Corpus ID: 6852423

Simultaneous quantification of loxapine, loxapine N-oxide, amoxapine, 8-hydroxyloxapine and 7-hydroxyloxapine in human plasma using LC-MS/MS.

@article{Meng2017SimultaneousQO,
  title={Simultaneous quantification of loxapine, loxapine N-oxide, amoxapine, 8-hydroxyloxapine and 7-hydroxyloxapine in human plasma using LC-MS/MS.},
  author={M. Meng and N. Zhao and Carrie C Pederson and Edward A. Harrison and Charisse Green and S. Gorman and S. Reuschel},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2017},
  volume={1046},
  pages={
          87-97
        }
}

M. Meng, N. Zhao, +4 authors S. Reuschel

Published 2017

Chemistry, Medicine

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Loxapine is an antipsychotic medication used for the treatment of schizophrenia. In vivo, loxapine is metabolized to multiple metabolites. A high performance liquid chromatographic-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of loxapine and 4 of its metabolites, loxapine N-oxide, amoxapine (N-desmethyl loxapine), 8-hydroxyloxapine and 7-hydroxyloxapine, in human plasma to support regulated clinical development. During method development… CONTINUE READING

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