Simultaneous quantification of acylcarnitine isomers containing dicarboxylic acylcarnitines in human serum and urine by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.

@article{Maeda2007SimultaneousQO,
  title={Simultaneous quantification of acylcarnitine isomers containing dicarboxylic acylcarnitines in human serum and urine by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.},
  author={Yasuhiro Maeda and Tetsuya Ito and Atsuko Suzuki and Yukihisa Kurono and Akihito Ueta and Kyoko Yokoi and Satoshi Sumi and Hajime Togari and Naruji Sugiyama},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2007},
  volume={21 5},
  pages={
          799-806
        }
}
Tandem mass spectrometry (MS/MS) has become a prominent method for screening newborns for diseases such as organic acidemia and fatty acid oxidation defects, although current methods cannot separate acylcarnitine isomers. Accurate determination of dicarboxylic acylcarnitines such as methylmalonylcarnitine and glutarylcarnitine has not been carried out, because obtaining standards of these acylcarnitines is difficult. We attempted the individual determinations of acylcarnitines with isomers and… CONTINUE READING

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