Simultaneous progression of oxidative stress and angiogenesis in malignant transformation of Barrett esophagus.

@article{Sihvo2003SimultaneousPO,
  title={Simultaneous progression of oxidative stress and angiogenesis in malignant transformation of Barrett esophagus.},
  author={Eero Sihvo and Terhi Ruohtula and Merja I Auvinen and Aki Koivistoinen and Ari L J Harjula and Jarmo A. Salo},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2003},
  volume={126 6},
  pages={1952-7}
}
BACKGROUND Oxidative stress and angiogenesis are important elements in the pathogenesis of inflammatory diseases and cancer. Our aim was to evaluate the role of both and of antioxidant capacity in the metaplasia-dysplasia-adenocarcinoma sequence in Barrett epithelium. METHODS In mucosal specimens from 59 patients grouped as having symptomatic gastroesophageal reflux disease, Barrett epithelium, or adenocarcinoma in the esophagus, plus controls, we measured myeloperoxidase activity… CONTINUE READING