Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

@article{Paliard1988SimultaneousPO,
  title={Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.},
  author={Xavier Paliard and Ren{\`e} de Waal Malefijt and Hans Yssel and Dominique Blanchard and Marl{\`e}ne Dreux and John Abrams and Jolanda de Vries and Hergen Spits},
  journal={Journal of immunology},
  year={1988},
  volume={141 3},
  pages={
          849-55
        }
}
In the present study, we have investigated the ability of human T cells to secrete IL-2, IL-4, and IFN-gamma. IL-4 and IFN-gamma were quantified with enzymatic immunoassays and IL-2 with a biologic assay by using the murine IL-2-dependent cell line CTLL-2. PBL, stimulated with Con A or with a combination of the phorbol ester 13-O-tetradecanoylphorbol-12-acetate and the Ca2+ ionophore A23187 secreted IL-2, IL-4, and IFN-gamma. The kinetics of the secretion of the three lymphokines was… CONTINUE READING

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