Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess

@article{Boghigian2011SimultaneousPA,
  title={Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess},
  author={B. Boghigian and M. Myint and Jiequn Wu and B. Pfeifer},
  journal={Journal of Industrial Microbiology & Biotechnology},
  year={2011},
  volume={38},
  pages={1809-1820}
}
  • B. Boghigian, M. Myint, +1 author B. Pfeifer
  • Published 2011
  • Medicine, Biology
  • Journal of Industrial Microbiology & Biotechnology
    • Natural products have long served as rich sources of drugs possessing a wide range of pharmacological activities. The discovery and development of natural product drug candidates is often hampered by the inability to efficiently scale and produce a molecule of interest, due to inherent qualities of the native producer. Heterologous biosynthesis in an engineering and process-friendly host emerged as an option to produce complex natural products. Escherichia coli has previously been utilized to… CONTINUE READING
    View on Springer
    ncbi.nlm.nih.gov
    11 Citations
    Background Citations
    3
    Methods Citations
    1

    Figures, Tables, and Topics from this paper

    Figures and Tables

    Explore Further: Topics Discussed in This Paper

    11 Citations
    Citation Type

    Citation Type

    Bioprocess engineering for microbial synthesis and conversion of isoprenoids.
    • 10
    Computational identification of gene over-expression targets for metabolic engineering of taxadiene production
    • 46
    Identification, characterization and molecular adaptation of class I redox systems for the production of hydroxylated
    Identification, characterization and molecular adaptation of class I redox systems for the production of hydroxylated diterpenoids
    • 6
    Improved Production and In Situ Recovery of Sesquiterpene (+)-Zizaene from Metabolically-Engineered E. coli
    • PDF
    In situ product removal in fermentation systems: improved process performance and rational extractant selection
    • 43
    • PDF
    Validating theoretical approaches for the generation of terpene macrocycles and their functional decoration by targeted protein engineering
    • PDF
    Screening of organic solvents for bioprocesses using aqueous-organic two-phase systems.
    • 21
    • PDF
    Advances in in-situ product recovery (ISPR) in whole cell biotechnology during the last decade.
    • 88
    Identification of reproducible drug-resistance-related dysregulated genes in small-scale cancer cell line experiments
    • 10
    • PDF

    References

    SHOWING 1-10 OF 70 REFERENCES
    Engineered biosynthesis of a complete macrolactone in a heterologous host.
    • 208
    Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
    • 1,367
    • PDF
    The chemical versatility of natural-product assembly lines.
    • C. Walsh
    • Chemistry, Medicine
    • Accounts of chemical research
    • 2008
    • 162
    Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases
    • 81
    Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli
    • 559
    Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli.
    • 371
    Current status, strategies, and potential for the metabolic engineering of heterologous polyketides in Escherichia coli
    • 31
    Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
    • 1,138
    Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production.
    • 295
    Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae.
    • 264