Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess

  title={Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess},
  author={B. Boghigian and M. Myint and Jiequn Wu and B. Pfeifer},
  journal={Journal of Industrial Microbiology & Biotechnology},
  • B. Boghigian, M. Myint, +1 author B. Pfeifer
  • Published 2011
  • Medicine, Biology
  • Journal of Industrial Microbiology & Biotechnology
  • Natural products have long served as rich sources of drugs possessing a wide range of pharmacological activities. The discovery and development of natural product drug candidates is often hampered by the inability to efficiently scale and produce a molecule of interest, due to inherent qualities of the native producer. Heterologous biosynthesis in an engineering and process-friendly host emerged as an option to produce complex natural products. Escherichia coli has previously been utilized to… CONTINUE READING
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