Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess

@article{Boghigian2011SimultaneousPA,
  title={Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess},
  author={B. Boghigian and M. Myint and Jiequn Wu and B. Pfeifer},
  journal={Journal of Industrial Microbiology & Biotechnology},
  year={2011},
  volume={38},
  pages={1809-1820}
}
  • B. Boghigian, M. Myint, +1 author B. Pfeifer
  • Published 2011
  • Medicine, Biology
  • Journal of Industrial Microbiology & Biotechnology
  • Natural products have long served as rich sources of drugs possessing a wide range of pharmacological activities. The discovery and development of natural product drug candidates is often hampered by the inability to efficiently scale and produce a molecule of interest, due to inherent qualities of the native producer. Heterologous biosynthesis in an engineering and process-friendly host emerged as an option to produce complex natural products. Escherichia coli has previously been utilized to… CONTINUE READING
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    References

    SHOWING 1-10 OF 70 REFERENCES
    Engineered biosynthesis of a complete macrolactone in a heterologous host.
    • 208
    Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
    • 1,367
    • PDF
    The chemical versatility of natural-product assembly lines.
    • C. Walsh
    • Chemistry, Medicine
    • Accounts of chemical research
    • 2008
    • 162
    Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases
    • 81
    Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli
    • 559
    Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli.
    • 371
    Current status, strategies, and potential for the metabolic engineering of heterologous polyketides in Escherichia coli
    • 31
    Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
    • 1,138
    Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae.
    • 264