Simultaneous permeation of tamoxifen and gamma linolenic acid across excised human skin. Further evidence of the permeation of solvated complexes.

@article{Karia2004SimultaneousPO,
  title={Simultaneous permeation of tamoxifen and gamma linolenic acid across excised human skin. Further evidence of the permeation of solvated complexes.},
  author={Clare Karia and J. Harwood and Andrew P Morris and C. Heard},
  journal={International journal of pharmaceutics},
  year={2004},
  volume={271 1-2},
  pages={
          305-9
        }
}
Tamoxifen is the hormonal treatment of choice in women who have hormone-dependent breast cancer and its efficacy in those women considered to have a high risk of developing breast cancer, has also been established. Gamma linolenic acid (GLA) has been shown to decrease the invasion of breast cancer and recent studies have demonstrated that GLA can enhance the oestrogen receptor down-regulation induced by tamoxifen. However, tamoxifen is associated with serious side-effects due mainly to systemic… Expand
In‐vitro transcutaneous delivery of tamoxifen and γ‐linolenic acid from borage oil containing ethanol and 1,8‐cineole
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