Simultaneous orientation and cellular force measurements in adult cardiac myocytes using three-dimensional polymeric microstructures.

@article{Zhao2007SimultaneousOA,
  title={Simultaneous orientation and cellular force measurements in adult cardiac myocytes using three-dimensional polymeric microstructures.},
  author={Yi Zhao and Chee Chew Lim and Douglas Brian Sawyer and Ronglih Liao and Xin Zhang},
  journal={Cell motility and the cytoskeleton},
  year={2007},
  volume={64 9},
  pages={718-25}
}
A number of techniques have been developed to monitor contractile function in isolated cardiac myocytes. While invaluable observations have been gained from these methodologies in understanding the contractile processes of the heart, they are invariably limited by their in vitro conditions. The present challenge is to develop innovative assays to mimic the in vivo milieu so as to allow a more physiological assessment of cardiac myocyte contractile forces. Here we demonstrate the use of a… CONTINUE READING

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