Simultaneous oral therapeutic and intravenous ¹⁴C-microdoses to determine the absolute oral bioavailability of saxagliptin and dapagliflozin.

@article{Boulton2013SimultaneousOT,
  title={Simultaneous oral therapeutic and intravenous ¹⁴C-microdoses to determine the absolute oral bioavailability of saxagliptin and dapagliflozin.},
  author={David Boulton and Sreeneeranj Kasichayanula and Chi Fung Anther Keung and Mark E. Arnold and Lisa J. Christopher and Xiaohui Sophia Xu and Frank P Lacreta},
  journal={British journal of clinical pharmacology},
  year={2013},
  volume={75 3},
  pages={763-8}
}
AIM To determine the absolute oral bioavailability (F(p.o.) ) of saxagliptin and dapagliflozin using simultaneous intravenous ¹⁴C-microdose/therapeutic oral dosing (i.v.micro + oraltherap). METHODS The F(p.o.) values of saxagliptin and dapagliflozin were determined in healthy subjects (n = 7 and 8, respectively) following the concomitant administration of single i.v. micro doses with unlabelled oraltherap doses. Accelerator mass spectrometry and liquid chromatography-tandem mass spectrometry… CONTINUE READING

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Characterization of the in vitro and in vivo metabolism and disposition and cytochrome p450 inhibition/induction profile of saxagliptin in human

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Achieving regulatory approval : Overcoming bioanalytical challenges in an Onglyza TM Micro - tracer Absolute Bioavailability Study with accelerator mass spectrometry

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